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Bifidobacterium breve HNXY26M4 attenuates cognitive deficits and neuroinflammation by regulating the gutbrain axis in APP/PS1 mice

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20-24 hr functional duration Diazepam 20-100 hours Feature Primary use Selank Anxiolytic / nootropic Semax Nootropic / neuroprotective Diazepam Anxiolytic / sedative / anticonvulsant Feature Daily dose Selank 250-500 mcg SubQ Semax 300-800 mcg SubQ Diazepam 2-10 mg oral Feature FDA status Selank Not approved Semax Not approved Diazepam FDA-approved Feature Dependence risk Selank None reported in published Russian trials Semax None reported in published Russian trials Diazepam Significant (Schedule IV) Feature Cognitive effects Selank Mild nootropic (memory, attention) Semax Stronger nootropic (memory, learning, focus) Diazepam Impairs memory and cognition Diazepam is included as a benzodiazepine reference, not as a recommendation

J Oncol

the stimulation of collagen synthesis was roughly twice that of non-collagen proteins, and type I and type III collagen messenger RNAs rose while an inactive control tripeptide produced no significant effect